BAK1 (BCL2-antagonist/killer 1)
نویسندگان
چکیده
منابع مشابه
Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment
Age-related hearing impairment (ARHI) is a progressive and a common sensory disorder in the elderly and will become an increasingly important clinical problem given the growing elderly population. Apoptosis of cochlear cells is an important factor in animal models of ARHI. As these cells cannot regenerate, their loss leads to irreversible hearing impairment. Identification of molecular mechanis...
متن کاملBAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy
Disruption of the complex of BECN1 with BCL2 or BCL2L1/BCL-XL is an essential switch that turns on cellular autophagy in response to environmental stress or treatment with BH3 peptidomimetics. Recently, it has been proposed that BCL2 and BCL2L1/BCL-XL may inhibit autophagy indirectly through a mechanism dependent on the proapoptotic BCL2 family members, BAX and BAK1. Here we report that the BH3...
متن کاملBAK1 Gene Variation: the doubts remain
Introduction Since Gottlieb et al. [2009] published some intriguing sequence differences between DNA obtained from abdominal aortic (AA) tissue and blood, the scientific community has been attempting to understand their findings. Dr. Gottlieb’s group was primarily interested in performing case-control association analyses in abdominal aortic aneurysm (AAA) patients. However, instead of obtainin...
متن کاملBAG1 (BCL2-associated athanogene)
Identity Other names: BAG-1, HAP, HAP46, RAP46 HGNC (Hugo): BAG1 Location: 9p13.3 DNA/RNA Description Centromere to telomerase orientation; 7 exons. Transcription 5 alternative transcripts; 1079 nucleotides mRNA. Protein Description Three isoforms generated by alternative translation initiation; 50kDa (BAG-1L), 46kDa (BAG-1M) and 36kDa (BAG-1S)(Yang et al., 1998). Each BAG-1 isoform contains a ...
متن کاملCell Signalling: The Merry Lives of BAK1
Plant receptor-like kinases characterised by leucine-rich repeats have been shown to play dual roles in seemingly unrelated biological processes, inviting comparison with TOLL-like receptors of animals.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44896